San Francisco (11-4) rides a five-game winning streak into a matchup with Chicago (11-4) on Sunday, December 28, 2025 at Levi’s Stadium. The 49ers are listed as favorites in this one, with the spread sitting at 3.5 points. An over/under of 51.5 points has been set for the contest.

Last time around, the Bears defeated the Green Bay Packers, with 22-16 being the final score.

In that matchup versus the Packers, Bears QB Caleb Williams completed 19 of 34 passes for 250 yards, with two touchdowns and no interceptions.

In their last action, the 49ers won against the Indianapolis Colts, 48-27.

Bears vs 49ers betting information

NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 6:07 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

• Spread favorite: San Francisco (-3.5)
• Moneyline: San Francisco (-193), Chicago (+160)
• Total: 51.5 points

Bears betting insights

• Chicago is 5-3 against the spread, and 5-3 overall, in away games.
• The Bears have covered the spread in a game 10 times this year (10-5-0).
• Chicago has two wins ATS (2-2) away from home as 3.5-point underdogs or more.
• The Bears are 2-2 ATS when playing as at least 3.5-point underdogs.
• This year, in five of eight road games Chicago has gone over the total.
• This season, seven Bears games have gone over the point total.

Bears leaders

• Williams: 3,400 PASS YDS / 226.7 YPG / 57.8% / 23 TD / 6 INT / 71 CAR / 369 RUSH YDS / 3 TD
• D’Andre Swift: 204 CAR / 993 YDS / 70.9 YPG / 7 TD / 31 REC / 266 YDS / 19 YPG / 1 TD
• Kyle Monangai: 155 CAR / 731 YDS / 48.7 YPG / 5 TD / 14 REC / 140 YDS / 9.3 YPG / 0 TD
• D.J. Moore: 48 REC / 664 YDS / 44.3 YPG / 6 TD
• Rome Odunze: 44 REC / 661 YDS / 55.1 YPG / 6 TD
• Colston Loveland: 42 REC / 528 YDS / 37.7 YPG / 4 TD

Bears vs 49ers game info

• Date: Sunday, December 28, 2025
• Time: 8:20 p.m. ET
• City: Santa Clara, California
• Venue: Levi’s Stadium
• TV channel: NBC/Peacock
• Live stream: Watch on Fubo (Regional restrictions may apply)

Watch San Francisco 49ers vs. Chicago Bears on Fubo! (Regional restrictions may apply)