Sunday’s game between the Cleveland Guardians (92-69) and the Houston Astros (88-73) at Progressive Field should be a close matchup, as our computer prediction projects a final score of 5-4, with the Guardians coming out on top. First pitch is at 3:10 p.m. ET on Sept. 29.

Place your bets on any MLB matchup at BetMGM, and sign up with our link for a first-time deposit bonus!

Guardians vs. Astros Matchup Info

• When: Sunday, September 29, 2024 at 3:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to Watch on TV: BSGL
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)
• Tickets: Get tickets for this game at Ticketmaster

MLB is back on Apple TV+! Watch two live games every week, daily coverage, and more.

Guardians vs. Astros Predictions

• Score Prediction: Guardians 5, Astros 4
• Total Prediction: Over 7.5 runs

Bet on this or any MLB matchup at BetMGM

Guardians vs. Astros Betting Lines

Get tickets for any MLB game this season at Ticketmaster!

Guardians Betting Insights

• Cleveland has been victorious in 64, or 63.4%, of the 101 contests it has been chosen as the favorite in this season.
• The Guardians have a win-loss record of 16-10 when favored by -162 or better by oddsmakers this year.
• Cleveland and its opponents have gone over the total this season in 69 of 161 opportunities.
• The Guardians went 5-6 across the 11 games in which they were moneyline favorites in their past 15 matchups.
• Over its past 15 matchups (all 15 of them had set totals), Cleveland and its opponents combined to hit the over two times.

Astros Betting Insights

• Houston has won 48.8% of the games this season it was the moneyline underdog (21-22).
• In games they have played as a moneyline underdog with odds of +136 or longer, the Astros have a 1-2 record (winning just 33.3% of their games).
• Houston has combined with opponents to hit the over on the total 65 times this season for a 65-89-7 record against the over/under.
• In five games over their past 15 matchups when set as underdogs by bookmakers, the Astros had a record of 3-2.
• In its past 15 games with a total, Houston and its opponents have combined to hit the over five times.

Catch MLB action all season long on ESPN+!

Guardians vs. Astros Probable Pitchers

Guardians’ Starting Pitcher: Nick Sandlin

• He has pitched in 68 games this season with an ERA of 3.75, a 2.52 strikeout to walk ratio and a WHIP of 1.266.
• This will be Nick Sandlin’s first start this season with his team as the moneyline favorite.
• Sandlin’s team lost in his only start this season.
• The only game started by Sandlin with a total this season hit the under.

Astros’ Starting Pitcher: Ryan Gusto

• Gusto’s team was never the underdog on the moneyline a season ago in games he pitched.

Rep your team with officially licensed MLB gear! Head to Fanatics to find jerseys, shirts, and much more.

Guardians’ 2024 Performance

Astros’ 2024 Performance

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.