Friday’s game features the Cleveland Guardians (92-67) and the Houston Astros (86-73) squaring off at Progressive Field in what should be a competitive matchup, with a projected 5-4 win for the Guardians according to our computer prediction. Game time is at 7:10 p.m. ET on Sept. 27.

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Guardians vs. Astros Matchup Info

• When: Friday, September 27, 2024 at 7:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to Watch on TV: MLB Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)
• Tickets: Get tickets for this game at Ticketmaster

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Guardians vs. Astros Predictions

• Score Prediction: Guardians 5, Astros 4
• Total Prediction: Over 8 runs

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Guardians vs. Astros Betting Lines

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Guardians Betting Insights

• Cleveland has won 64, or 64.6%, of the 99 contests it has been named as the odds-on favorite in this year.
• This year, the Guardians have won 51 of 76 games when listed as at least -125 or better on the moneyline.
• Cleveland and its opponents have gone over the total this season in 69 of 159 opportunities.
• The Guardians went 7-4 across the 11 games in which they were favored on the moneyline in their past 15 matchups.
• In its past 15 matchups — all had a set run total — Cleveland and its opponents combined to hit the over on the total three times.

Astros Betting Insights

• Houston is 19-22 in games it was the underdog on the moneyline (winning 46.3% of those games).
• When playing as a moneyline underdog with odds of +105 or longer, the Astros have gone 9-9 (50%).
• Houston has combined with opponents to go over the total 65 times this season for a 65-87-7 record against the over/under.
• The Astros have played as underdogs in three of their past 15 games and won one of those contests.
• Houston and its opponents have combined to hit the over seven times in its past 15 games with a total.

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Guardians vs. Astros Probable Pitchers

Guardians’ Starting Pitcher: Joey Cantillo

• The 24-year-old has pitched to a 4.63 ERA this season with 9.5 strikeouts per nine innings compared to 3.3 walks per nine across eight games.
• Joey Cantillo’s team is 2-0 this season when he starts and they’re favored on the moneyline.
• Cantillo’s team has a 4-3 record in his starts this season.
• Games started by Cantillo have a 2-5-0 record at hitting the over this season.

Astros’ Starting Pitcher: Ronel Blanco

• The 31-year-old has put together a 2.88 ERA and 9 strikeouts per nine innings in 29 games this season, while allowing a batting average of .193 to opposing hitters.
• The Astros are 5-3 in Blanco’s eight starts this season that they were the moneyline underdog.
• Blanco’s team has a 19-9 record in his starts this season.
• Ronel Blanco has had 28 starts with a set total this season, and the teams combined to go over the total in 11 of those outings.

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Guardians’ 2024 Performance

Astros’ 2024 Performance

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