Wednesday’s contest features the Houston Astros (86-72) and the Seattle Mariners (81-77) matching up at Minute Maid Park in what should be a close matchup, with a projected 5-4 victory for the Astros according to our computer prediction. Game time is at 2:10 p.m. ET on Sept. 25.

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Astros vs. Mariners Matchup Info

• When: Wednesday, September 25, 2024 at 2:10 p.m. ET
• Where: Minute Maid Park in Houston, Texas
• How to Watch on TV: SCHN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)
• Tickets: Get tickets for this game at Ticketmaster

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Astros vs. Mariners Predictions

• Score Prediction: Astros 5, Mariners 4
• Total Prediction: Over 7 runs

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Astros vs. Mariners Betting Lines

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Astros Betting Insights

• Houston has won 66, or 57.4%, of the 115 contests it has been named as the odds-on favorite in this year.
• The Astros have a mark of 51-32 in contests where sportsbooks favor them by -135 or better on the moneyline.
• Houston’s games have gone over the total in 64 of 158 opportunities.
• The Astros played as the moneyline favorite in 12 of their past 15 games, and they went 8-4 in those matchups.
• Over its past 15 matchups, Houston and its opponents combined to go over the total six times (all 15 games had set totals).

Mariners Betting Insights

• Seattle has won 40.4% of the games this season it was the moneyline underdog (21-31).
• The Mariners have a record of 7-10 when playing as a moneyline underdog with odds of +114 or longer (41.2%).
• Seattle has had an over/under set by bookmakers 158 times, and it has combined with opponents to go over the total in 73 of those games (73-74-11).
• In seven games over their past 15 matchups when set as underdogs by oddsmakers, the Mariners had a record of 4-3.
• In its past 15 games with a total, Seattle and its opponents are 9-3-3 when it comes to hitting the over.

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Astros vs. Mariners Probable Pitchers

Astros’ Starting Pitcher: Yusei Kikuchi

• The 33-year-old has an ERA of 4.19, a 4.6 strikeout-to-walk ratio and a WHIP of 1.214 in 31 games this season.
• When Yusei Kikuchi starts a game and his team is the favorite on the moneyline, they have a record of 13-9.
• Kikuchi’s team is 16-15 when he starts this season.
• In Kikuchi’s 31 starts with a total, the teams have hit the over 16 times.

Mariners’ Starting Pitcher: George Kirby

• In 32 games this season, the 26-year-old has an ERA of 3.60, with 8.4 strikeouts per nine innings. Opponents are hitting .247 against him.
• The Mariners are 2-5 in Kirby’s seven starts this season that they were the moneyline underdog.
• In Kirby’s 32 starts, his team is 15-17.
• Kirby’s starts went over the run total 17 times in 32 games with a set total this season.

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Astros’ 2024 Performance

Mariners’ 2024 Performance

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