Sunday’s contest between the St. Louis Cardinals (78-77) and the Cleveland Guardians (90-66) at Busch Stadium should be a tight matchup, as our computer prediction projects a final score of 5-4, with the Cardinals coming out on top. Game time is at 2:15 p.m. ET on Sept. 22.

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Cardinals vs. Guardians Matchup Info

• When: Sunday, September 22, 2024 at 2:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: BSGL
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)
• Tickets: Get tickets for this game at Ticketmaster

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Cardinals vs. Guardians Predictions

• Score Prediction: Cardinals 5, Guardians 4
• Total Prediction: Over 7.5 runs

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Cardinals vs. Guardians Betting Lines

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Cardinals Betting Insights

• St. Louis has come away with 36 wins in the 73 contests it has been listed as the favorite in this season.
• This season, the Cardinals have been victorious 25 times in 53 chances when named as a favorite of at least -122 or better on the moneyline.
• St. Louis and its opponents have gone over the total this season in 70 of 154 opportunities.
• The Cardinals played as the moneyline favorite in seven of their past 15 games, and they finished 4-3 in those matchups.
• In its past 15 outings (all 15 of them had set totals), St. Louis and its opponents combined to go over the run total four times.

Guardians Betting Insights

• Cleveland has been the moneyline underdog 58 total times this season. It has gone 27-31 in those games.
• In games they have played as a moneyline underdog with odds of +102 or longer, the Guardians have gone 15-24 (38.5%).
• In the 156 games bookmakers have set an over/under for Cleveland, it has combined with opponents to go over the total 69 times (69-77-10).
• In four games as underdogs in their past 15 matchups, the Guardians have a record of 2-2.
• Cleveland and its opponents have combined to hit the over three times in its past 15 games with a total.

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Cardinals vs. Guardians Probable Pitchers

Cardinals’ Starting Pitcher: Andre Pallante

• The 26-year-old has pitched in 27 games this season with a 3.87 ERA and 7.1 strikeouts per nine innings with a batting average against of .245.
• Andre Pallante’s team has won 50% of his starts when they are favored on the moneyline (3-3).
• Pallante’s team has a 9-9 record in his starts this season.
• Games Pallante has started this season hit the over six times in 18 chances.

Guardians’ Starting Pitcher: Gavin Williams

• In 15 games this season, the 25-year-old has amassed an ERA of 5.12, with 9.7 strikeouts per nine innings. Opponents are hitting .249 against him.
• The Guardians are 2-3 in Williams’ five starts this season that they were the moneyline underdog.
• Williams’ team is 4-11 over his 15 starts.
• Gavin Williams has had 15 starts with a total this season, and the teams combined to go over the total in three of those games.

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Cardinals’ 2024 Performance

Guardians’ 2024 Performance

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