Saturday’s game between the St. Louis Cardinals (77-77) and Cleveland Guardians (90-65) squaring off at Busch Stadium has a projected final score of 5-4 (according to our computer prediction) in favor of the Cardinals, so expect a competitive matchup. The game will begin at 7:15 p.m. ET on Sept. 21.

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Cardinals vs. Guardians Matchup Info

• When: Saturday, September 21, 2024 at 7:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: BSGL
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)
• Tickets: Get tickets for this game at Ticketmaster

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Cardinals vs. Guardians Predictions

• Score Prediction: Cardinals 5, Guardians 4
• Total Prediction: Over 8 runs

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Cardinals vs. Guardians Betting Lines

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Cardinals Betting Insights

• St. Louis has been victorious in 36, or 49.3%, of the 73 contests it has been chosen as the favorite in this season.
• This season, the Cardinals have come away with a win 31 times in 63 chances when named as a favorite of at least -118 or better on the moneyline.
• St. Louis’ games have gone over the total in 69 of 153 opportunities.
• The Cardinals played as the moneyline favorite in seven of their past 15 games, and they went 4-3 in those matchups.
• In its past 15 matchups (all had set totals), St. Louis combined with its opponents to go over the run total three times.

Guardians Betting Insights

• Cleveland is 27-31 in games it was the underdog on the moneyline (winning 46.6% of those games).
• The Guardians have a 19-26 record (winning 42.2% of their games) when playing as a moneyline underdog of -102 or longer.
• Cleveland has played in 155 games with an over/under set, and it has combined with its opponents to go over the total 68 times (68-77-10).
• In five games as underdogs in their past 15 matchups, the Guardians had a record of 3-2.
• In its past 15 games with a total, Cleveland and its opponents have failed to hit the over 13 times.

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Cardinals vs. Guardians Probable Pitchers

Cardinals’ Starting Pitcher: Miles Mikolas

• The 36-year-old has an ERA of 5.49, a 4.75 strikeout-to-walk ratio and a WHIP of 1.288 in 30 games this season.
• Miles Mikolas’ team has been victorious in 25% of the games he’s started as the moneyline favorite with a record of 2-6.
• Mikolas’ team is 14-16 when he starts this season.
• Games Mikolas has started this season hit the over 13 times in 30 chances.

Guardians’ Starting Pitcher: Matthew Boyd

• The 33-year-old has a 2.52 ERA and 10.1 strikeouts per nine innings during seven games this season, while giving up a batting average of .209 to opposing batters.
• The Guardians were the moneyline underdog for three Matthew Boyd starts this season — they won every time.
• Boyd’s team has a 6-1 record in his starts this season.
• Boyd has had seven starts that sportsbooks set a total for this season, and two of those outings hit the over.

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Cardinals’ 2024 Performance

Guardians’ 2024 Performance

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