Friday’s contest features the St. Louis Cardinals (77-76) and the Cleveland Guardians (89-65) matching up at Busch Stadium in what should be a close matchup, with a projected 5-4 win for the Cardinals according to our computer prediction. Game time is at 8:15 p.m. ET on Sept. 20.

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Cardinals vs. Guardians Matchup Info

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Cardinals vs. Guardians Predictions

  • Score Prediction: Cardinals 5, Guardians 4
  • Total Prediction: Over 8.5 runs

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Cardinals vs. Guardians Betting Lines

Cardinals vs Guardians Betting Information
Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds
Cardinals -115 -105 8.5 -104 -125

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Cardinals Betting Insights

  • St. Louis has come away with 36 wins in the 72 contests it has been listed as the favorite in this season.
  • This season, the Cardinals have been victorious 33 times in 67 chances when named as a favorite of at least -115 or better on the moneyline.
  • St. Louis and its opponents have gone over in 69 of 152 games with a total set by sportsbooks this season.
  • The Cardinals had a 4-2 record over the six games they were favored on the moneyline in their past 15 matchups.
  • Over its past 15 outings (all had set totals), St. Louis combined with its opponents to hit the over on the run total four times.

Guardians Betting Insights

  • Cleveland has won 26 of the 57 games it was the moneyline underdog this season (45.6%).
  • In games they have played as a moneyline underdog with odds of -105 or longer, the Guardians have a 20-29 record (winning 40.8% of their games).
  • Cleveland has combined with opponents to go over the total 68 times this season for a 68-76-10 record against the over/under.
  • The Guardians have played as underdogs in five of their past 15 games and won two of those contests.
  • Cleveland and its opponents have combined to hit the over two times in its past 15 games with a total.

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Cardinals vs. Guardians Probable Pitchers

Cardinals’ Starting Pitcher: Kyle Gibson

  • The 36-year-old has pitched to a 4.11 ERA this season with 8.1 strikeouts per nine innings compared to 3.5 walks per nine across 28 games.
  • Kyle Gibson’s team has been victorious in 41.7% of the games he’s started as the moneyline favorite with a record of 5-7.
  • Gibson’s team has won 14 of his 28 starts.
  • In Gibson’s 28 starts with a total, the teams have hit the over 16 times.

Guardians’ Starting Pitcher: Ben Lively

  • The 32-year-old has put up an ERA of 3.87, with 7.1 strikeouts per nine innings in 27 games this season. Opponents are batting .242 against him.
  • The Guardians have a 3-6 record in Lively’s nine starts this season when they were the underdog on the moneyline.
  • In Lively’s 27 starts, his team is 17-10.
  • Ben Lively has started 27 games with a total set by bookmakers this season. The teams have combined to hit the over in 10 of them.

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Cardinals’ 2024 Performance

Split Record
Overall 77-76
Home 42-36
Road 35-40
One-Run Games 27-21
Scoring 5+ Runs 45-12

Guardians’ 2024 Performance

Split Record
Overall 89-65
Home 48-28
Road 41-37
One-Run Games 26-16
Scoring 5+ Runs 63-8

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