There are 64 FBS games on the Week 4 slate, with Baylor vs. Colorado among the best bets in terms of the over/under, based on our projections. For more tips, including parlay opportunities, see below.

See computer predictions and insights for that game and more in the article below.

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College Football Computer Picks – Best Spread Bets

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Pick: Bowling Green +23.5 vs. Texas A&M

• Matchup: Bowling Green Falcons at Texas A&M Aggies
• Projected Winner & Margin: Texas A&M by 2.8 points
• Time: 7:30 PM ET
• Date: Sept. 21
• TV Channel: SEC Network+

Pick: UCLA +24 vs. LSU

• Matchup: UCLA Bruins at LSU Tigers
• Projected Winner & Margin: LSU by 6.5 points
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Charlotte +28.5 vs. Indiana

• Matchup: Charlotte 49ers at Indiana Hoosiers
• Projected Winner & Margin: Indiana by 11.7 points
• Time: 12:00 PM ET
• Date: Sept. 21
• TV Channel: BTN

Pick: Ohio +19.5 vs. Kentucky

• Matchup: Ohio Bobcats at Kentucky Wildcats
• Projected Winner & Margin: Kentucky by 3.2 points
• Time: 12:45 PM ET
• Date: Sept. 21
• TV Channel: SEC Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Akron +27.5 vs. South Carolina

• Matchup: Akron Zips at South Carolina Gamecocks
• Projected Winner & Margin: South Carolina by 12.4 points
• Time: 7:30 PM ET
• Date: Sept. 21
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Use these spread picks at BetMGM today!

College Football Computer Picks – Best Total Bets

Under 52.5 – Baylor vs. Colorado

• Matchup: Baylor Bears at Colorado Buffaloes
• Projected Total: 36 points
• Time: 8:00 PM ET
• Date: Sept. 21
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 55.5 – San Jose State vs. Washington State

• Matchup: San Jose State Spartans at Washington State Cougars
• Projected Total: 40.3 points
• Time: 10:00 PM ET
• Date: Sept. 20
• TV Channel: The CW
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 55.5 – Wyoming vs. North Texas

• Matchup: Wyoming Cowboys at North Texas Mean Green
• Projected Total: 70 points
• Time: 7:00 PM ET
• Date: Sept. 21
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Under 54.5 – East Carolina vs. Liberty

• Matchup: East Carolina Pirates at Liberty Flames
• Projected Total: 41.5 points
• Time: 6:00 PM ET
• Date: Sept. 21
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Over 48.5 – North Carolina State vs. Clemson

• Matchup: North Carolina State Wolfpack at Clemson Tigers
• Projected Total: 58.5 points
• Time: 12:00 PM ET
• Date: Sept. 21
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Take advantage of our picks and place your bet at BetMGM today!

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