Monday’s contest at Progressive Field has the Cleveland Guardians (86-64) matching up with the Minnesota Twins (79-70) at 6:40 p.m. ET (on Sept. 16). Our computer prediction projects a narrow 4-3 win for the Guardians, so it should be a competitive matchup.

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Twins vs. Guardians Matchup Info

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Twins vs. Guardians Predictions

  • Score Prediction: Guardians 4, Twins 3
  • Total Prediction: Under 7.5 runs

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Twins vs. Guardians Betting Lines

Twins vs Guardians Betting Information
Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds
Twins -115 -105 7.5 -105 -115

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Twins Betting Insights

  • Minnesota has been the favorite in 102 games this season, and has come away with the win 62 times (60.8%) in those contests.
  • The Twins have a win-loss record of 59-40 when favored by -115 or better by oddsmakers this year.
  • Minnesota and its opponents have gone over the total this season in 76 of 148 opportunities.
  • The Twins played as the moneyline favorite in 12 of their past 15 games, and they went 6-6 in those matchups.
  • Over its past 15 matchups, Minnesota and its opponents combined to go over the run total eight times (all 15 games had set totals).

Guardians Betting Insights

  • Cleveland has won 44.6% of the games this season it was the underdog on the moneyline (25-31).
  • The Guardians have a 20-29 record (winning 40.8% of their games) when playing as a moneyline underdog of -105 or longer.
  • In the 150 games oddsmakers have set an over/under for Cleveland, it has combined with opponents to go over the total 67 times (67-73-10).
  • The Guardians have played as underdogs in five of their past 15 games and won two of those contests.
  • In its past 15 games with a total, Cleveland and its opponents have combined to hit the over just once.

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Twins vs. Guardians Probable Pitchers

Twins’ Starting Pitcher: Pablo Lopez

  • The 28-year-old has an ERA of 3.88 and 9.7 strikeouts per nine innings, with a batting average against of .243 in 29 games this season.
  • Pablo Lopez’s team is 17-6 this season when he starts and they are the moneyline favorite.
  • Lopez’s team has won 18 of his 29 starts.
  • Games started by Lopez have a 16-11-2 record at hitting the over this season.

Guardians’ Starting Pitcher: Matthew Boyd

  • Over six games this season, the 33-year-old has put up a 2.18 ERA and 9.5 strikeouts per nine innings, while allowing a batting average of .190 to opposing batters.
  • The Guardians were named the moneyline underdog for two Matthew Boyd starts this season — they won both.
  • Over Boyd’s six starts, his team is 5-1.
  • Boyd has had six starts with a set total this season, and the teams combined to hit the over in two of those outings.

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Twins’ 2024 Performance

Split Record
Overall 79-70
Home 42-33
Road 37-37
One-Run Games 22-17
Scoring 5+ Runs 56-12

Guardians’ 2024 Performance

Split Record
Overall 86-64
Home 45-27
Road 41-37
One-Run Games 23-16
Scoring 5+ Runs 62-8

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