Monday’s game at Busch Stadium has the St. Louis Cardinals (74-75) squaring off against the Pittsburgh Pirates (71-78) at 7:45 p.m. ET (on Sept. 16). Our computer prediction projects a narrow 5-4 win for the Cardinals, so expect a competitive matchup.

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Pirates vs. Cardinals Matchup Info

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Pirates vs. Cardinals Predictions

  • Score Prediction: Cardinals 5, Pirates 4
  • Total Prediction: Over 7 runs

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Pirates vs. Cardinals Betting Lines

Pirates vs Cardinals Betting Information
Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds
Pirates -142 +120 7 -115 -105

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Pirates Betting Insights

  • Pittsburgh has won 36, or 57.1%, of the 63 contests it has been named as the odds-on favorite in this year.
  • This year, the Pirates have won 15 of 25 games when listed as at least -142 or better on the moneyline.
  • Pittsburgh’s games have gone over the total in 72 of 149 opportunities.
  • The Pirates went 7-3 over the 10 games in which they were favored on the moneyline in their past 15 matchups.
  • Over its past 15 matchups — all had a set run total — Pittsburgh and its opponents combined to hit the over on the total seven times.

Cardinals Betting Insights

  • St. Louis has compiled a 38-40 record in games it was the underdog on the moneyline (winning 48.7% of those games).
  • The Cardinals have a record of 9-16 when playing as a moneyline underdog with odds of +120 or longer (36%).
  • St. Louis has had an over/under set by bookmakers 148 times, and it has combined with opponents to go over the total in 68 of those games (68-74-6).
  • In 12 games as underdogs in their past 15 matchups, the Cardinals had a record of 5-7.
  • In its past 15 games with a total, St. Louis and its opponents have combined to hit the over seven times.

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Pirates vs. Cardinals Probable Pitchers

Pirates’ Starting Pitcher: Paul Skenes

  • The 22-year-old has pitched to a 2.10 ERA this season with 11.3 strikeouts per nine innings compared to 2.3 walks per nine across 20 games.
  • Paul Skenes’ team has a record of 12-6 this season when he starts and they are the favorite on the moneyline.
  • In games Skenes has started, his team is 13-7.
  • Games Skenes has started this season hit the over 10 times in 20 chances.

Cardinals’ Starting Pitcher: Andre Pallante

  • The 25-year-old has amassed an ERA of 4.13, with 6.8 strikeouts per nine innings in 26 games this season. Opposing hitters have a .250 batting average against him.
  • The Cardinals have a 5-6 record in Pallante’s 11 starts this season when they were the moneyline underdog.
  • Pallante’s team has won eight of his 17 starts.
  • Andre Pallante has started 17 contests with a total set by oddsmakers this season. The teams have combined to go over the run total in six of them.

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Pirates’ 2024 Performance

Split Record
Overall 71-78
Home 38-40
Road 33-38
One-Run Games 23-26
Scoring 5+ Runs 44-18

Cardinals’ 2024 Performance

Split Record
Overall 74-75
Home 39-35
Road 35-40
One-Run Games 27-20
Scoring 5+ Runs 44-12

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